abstract：:Heat shock proteins (Hsps) have been reported to be dominant antigens for the host immune response to various pathogens and thus, have great potential for use in vaccination. In the present study, we evaluated the immunogenicity and protective efficacy of GroEL of Salmonella enterica serovar Typhi against lethal infec...

journal_title：Molecular and cellular biochemistry

authors： Bansal A,Paliwal PK,Sagi SS,Sairam M

更新日期：2010-04-01 00:00:00

abstract：:Phospholipase C-beta (PLCbeta) isozymes (PLCbeta(1) and PLCbeta(3)) have been extensively characterized in cardiac tissue, but no data are available for the PLCbeta(4) isozyme. In this study, PLCbeta((1-4)) isozymes mRNA relative expression was studied by real-time PCR (RT-PCR) in human, rat, and murine left ventricle...

journal_title：Molecular and cellular biochemistry

authors： Otaegui D,Querejeta R,Arrieta A,Lazkano A,Bidaurrazaga A,Arriandiaga JR,Aldazabal P,Garro MA

更新日期：2010-04-01 00:00:00

abstract：:Studies show that genetic polymorphisms in apolipoproteins, which are in charge of lipid transport, predispose to atherogenic dyslipidemia. This study aimed to investigate the impact of apolipoprotein E, A5, and B genotypes and dietary intake on lipid profile in a sample of elderly women in Brazil. Two hundred and fif...

journal_title：Molecular and cellular biochemistry

authors： Paula RS,Souza VC,Benedet AL,Souza ER,Toledo JO,Moraes CF,Gomes L,Alho CS,Córdova C,Nóbrega OT

更新日期：2010-04-01 00:00:00

abstract：:Thioredoxin (Trx) is a small ubiquitous protein, which has been shown to be involved in redox-dependent cellular functions. In this article, we demonstrate that the increased level of Trx induces AP-1 DNA binding in a redox-dependent manner by activating JNK subgroup of MAPKs. The majority of AP-1 DNA binding complex ...

journal_title：Molecular and cellular biochemistry

authors： Das KC,Muniyappa H

更新日期：2010-04-01 00:00:00

abstract：:Resveratrol (trans-3,5,4'-trihydroxystilbene), a compound found largely in the skins of red grapes and wines, possesses anti-cancer and anti-angiogenic properties and protects the cardiovascular system. However, the molecular mechanisms by which resveratrol inhibits angiogenesis are currently subjects of intense inves...

journal_title：Molecular and cellular biochemistry

authors： Srivastava RK,Unterman TG,Shankar S

更新日期：2010-04-01 00:00:00

abstract：:CYP3A5 is an important genetic contributor to inter-individual differences in CYP3A-dependent clinically important drugs of metabolism and also of various endogenous compounds and environmental contaminants. The CYP3A5*3 allele results in a truncated protein with loss of CYP3A5 expression and CYP3A5*6 is associated wi...

journal_title：Molecular and cellular biochemistry

authors： Bajpai P,Tripathi AK,Agrawal D

更新日期：2010-03-01 00:00:00

abstract：:Glutathione acts as a protein disulphide reductant, which detoxifies herbicides by conjugation, either spontaneously or by the activity of one of a number of glutathione-S-transferases (GSTs), and regulates gene expression in response to environmental stress and pathogen attack. GSTs play roles in both normal cellular...

journal_title：Molecular and cellular biochemistry

authors： Banerjee S,Goswami R

更新日期：2010-03-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) increases the risk of cardiovascular morbid events in hypertension. TGF-beta1 is involved in pathologic states such as cardiac hypertrophy and cardiac fibrosis; we thus postulate that the TGF-beta1 polymorphism is related to LVH in hypertensives. Six hundred and eighty essential hype...

journal_title：Molecular and cellular biochemistry

authors： Xu HY,Hou XW,Wang LF,Wang NF,Xu J

更新日期：2010-02-01 00:00:00

abstract：:Human papillomavirus (HPV) is considered to be a major etiological factor but is not sufficient for the development of cervical cancer. Other host factors including altered tumor suppressor gene activities might contribute to the carcinogenic process. Fragile Histidine Triad (FHIT) has been shown to play a pivotal rol...

journal_title：Molecular and cellular biochemistry

authors： Neyaz MK,Hussain S,Hassan MI,Das BC,Husain SA,Bharadwaj M

更新日期：2010-02-01 00:00:00

abstract：:The manganese superoxide dismutase (MnSOD) ala16val polymorphism has been associated with various diseases including breast cancer. In the present study, we investigated levels of MnSOD protein, enzymatic activity, and mRNA with respect to MnSOD genotype in several human breast carcinoma cell lines and in mouse embryo...

journal_title：Molecular and cellular biochemistry

authors： McAtee BL,Yager JD

更新日期：2010-02-01 00:00:00

abstract：:Membranous guanylate cyclase in retinal photoreceptor outer segments (ROS-GC), a key enzyme for the recovery of photoreceptors to the dark state, has a topology identical to and cytoplasmic domains homologous to those of peptide-regulated GCs. However, under the prevailing concept, its activation mechanism is signific...

journal_title：Molecular and cellular biochemistry

authors： Bondarenko VA,Hayashi F,Usukura J,Yamazaki A

更新日期：2010-01-01 00:00:00

abstract：:Antimycin A (AMA) inhibits succinate oxidase, NADH oxidase, and mitochondrial electron transport chain between cytochrome b and c. We recently demonstrated that AMA inhibited the growth of Calu-6 lung cancer cells through apoptosis. Here, we investigated the effects of AMA and/or MAPK inhibitors on Calu-6 lung cancer ...

journal_title：Molecular and cellular biochemistry

authors： Han YH,Park WH

更新日期：2010-01-01 00:00:00

abstract：:HMGb1 is a DNA-binding protein whose role as an extracellular cytokine in inflammation and tissue regeneration has also been reported. Given the importance of keratinocytes in wound healing, we have studied the mechanism of action of HMGb1 on HaCaT keratinocytes during in vitro scratch wound repair. Western blot and c...

journal_title：Molecular and cellular biochemistry

authors： Ranzato E,Patrone M,Pedrazzi M,Burlando B

更新日期：2009-12-01 00:00:00

abstract：:Long-term survival of oxygen deprivation by animals with well-developed anoxia tolerance depends on multiple biochemical adaptations including strong metabolic rate depression. We investigated whether the AMP-activated protein kinase (AMPK) could play a regulatory role in the suppression of protein synthesis that occu...

journal_title：Molecular and cellular biochemistry

authors： Rider MH,Hussain N,Dilworth SM,Storey KB

更新日期：2009-12-01 00:00:00

abstract：:Both idiopathic restrictive cardiomyopathy (IRCM) and hypertrophic cardiomyopathy (HCM) are part of the same disease spectrum and are due to sarcomeric gene mutations. A patient with restrictive physiology without left ventricular hypertrophy (LVH) would be diagnosed as IRCM, while one with LVH would be diagnosed as H...

journal_title：Molecular and cellular biochemistry

authors： Rai TS,Ahmad S,Ahluwalia TS,Ahuja M,Bahl A,Saikia UN,Singh B,Talwar KK,Khullar M

更新日期：2009-11-01 00:00:00

abstract：:The present study was aimed to get the nucleotide sequences of a part of COII mitochondrial gene amplified from individuals of five species of Termites (Isoptera: Termitidae: Macrotermitinae). Four of them belonged to the genus Odontotermes (O. obesus, O. horni, O. bhagwatii and Odontotermes sp.) and one to Microterme...

journal_title：Molecular and cellular biochemistry

authors： Sobti RC,Kumari M,Sharma VL,Sodhi M,Mukesh M,Shouche Y

更新日期：2009-11-01 00:00:00

abstract：:It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could not be cleaved in type I cells, could be effectively cleaved by recombinant active caspase-8 in vitro. The clea...

journal_title：Molecular and cellular biochemistry

authors： Li Y,Qi L,Iwao A,Kihira K,Dida F,Song Z,Azuma E,Komada Y

更新日期：2009-11-01 00:00:00

abstract：:The T-786C, Glu298Asp, and 27 bp variable number of tandem repeats (27 bp-VNTR-a/b) polymorphsims of the endothelial nitric oxide synthase (eNOS) gene are thought to alter nitric oxide production and contribute to the development of vascular and renal disease risk. The objective of this study is to investigate whether...

journal_title：Molecular and cellular biochemistry

authors： Nath SD,He X,Voruganti VS,Blangero J,MacCluer JW,Comuzzie AG,Arar NH,Abboud HE,Thameem F

更新日期：2009-11-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) play an important role in the development of hepatic fibrosis. Heat shock protein 90 (Hsp90) is essential for the maturation and activity of a varied group of proteins involved in signal transduction and cell cycle regulation. In this study, we found that two Hsp90 inhibitors, VER-49009 a...

journal_title：Molecular and cellular biochemistry

authors： Sun X,Zhang XD,Cheng G,Hu YH,Wang HY

更新日期：2009-10-01 00:00:00

abstract：:Regulation of matrix metalloproteinase-13 (MMP-13) by collagen matrix in the synovial fibroblasts of rheumatoid arthritis (RA) is critical event in the progressive joint destruction. Our previous study indicated that a collagen receptor, discoidin receptor 2 (DDR2), was highly expressed in the synovial fibroblasts of ...

journal_title：Molecular and cellular biochemistry

authors： Su J,Yu J,Ren T,Zhang W,Zhang Y,Liu X,Sun T,Lu H,Miyazawa K,Yao L

更新日期：2009-10-01 00:00:00

abstract：:The mechanism of the effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein degradation induced by lipopolysaccharide (LPS) has been evaluated in murine myotubes. HMB (50 muM) completely attenuated total protein degradation induced by LPS (1-100 ng/ml), formation of reactive oxygen species (ROS) and activation of...

journal_title：Molecular and cellular biochemistry

authors： Russell ST,Tisdale MJ

更新日期：2009-10-01 00:00:00

abstract：:The influence of hypotonic solution on cell volume and electrophysiology properties of the failing heart of cardiomyopathic hamsters (TO-2) was investigated. The results showed an increase in cell volume of quiescent isolated ventricular myocytes by 66% within 30 min. Angiotensin (1-7) [Ang (1-7)] (10(-8) M) administe...

journal_title：Molecular and cellular biochemistry

authors： De Mello WC

更新日期：2009-10-01 00:00:00

abstract：:We investigated whether chronic in vivo treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates cardiac contractile function by impairing mitochondrial respiration. Wy-14,643 (25 mg kg(-1) day(-1)) was administered to Wistar rats by oral gavage for 14 consecutive days, after wh...

journal_title：Molecular and cellular biochemistry

authors： Zungu M,Young ME,Stanley WC,Essop MF

更新日期：2009-10-01 00:00:00

abstract：:Ventricular electrical conduction has been investigated in the streptozotocin (STZ)-induced diabetic rat. Diabetes was induced with a single injection of STZ (60 mg/kg bodyweight, ip). The ECG was measured continuously, in vivo, using a biotelemetry system. Left ventricular action potentials were recorded with an extr...

journal_title：Molecular and cellular biochemistry

authors： Howarth FC,Jacobson M,Qureshi MA,Shafiullah M,Hameed RS,Zilahi E,Al Haj A,Nowotny N,Adeghate E

更新日期：2009-08-01 00:00:00

abstract：:Prion protein (PrP) interacts with some kringle domain-containing proteins. Kringle domains serve as binding domains in the interaction with PrP. The structural conservation among kringle domains leads to the hypothesis that any protein containing these domains can interact with PrP and be involved in prion pathogenes...

journal_title：Molecular and cellular biochemistry

authors： Kim Y,Song J,Mays CE,Titlow W,Yoon D,Ryou C

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Chronic adenosine A2b receptor stimulation has been shown to prevent ventricular remodelling after myocardial infarction (MI). We hypothesized that this effect is due to the inhibition of cardiac myocyte apoptosis in the myocardium remote from the infarction. METHODS:Rats were subjected to MI by LAD ligation...

journal_title：Molecular and cellular biochemistry

authors： Simonis G,Wiedemann S,Joachim D,Weinbrenner C,Marquetant R,Strasser RH

更新日期：2009-08-01 00:00:00

abstract：:RGPR-p117 was originally discovered as a novel protein that binds to a nuclear factor I (NFI) consensus motif TTGGC(N)(6)CC, which is present in the 5'-flanking region of the regucalcin gene (rgn). RGPR-p117 has been identified in human, rat, mouse, bovine, rabbit, and chicken livers. Phylogenetic analysis of six vert...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M

更新日期：2009-07-01 00:00:00

abstract：:Hyperhomocysteinemia is associated with various pathologies including cardiovascular disease, stroke, and cognitive dysfunctions. Systemic administration of homocysteine can trigger seizures in animals, and patients with homocystinuria suffer from epileptic seizures. Available data suggest that homocysteine can be har...

journal_title：Molecular and cellular biochemistry

authors： Rasić-Marković A,Stanojlović O,Hrncić D,Krstić D,Colović M,Susić V,Radosavljević T,Djuric D

更新日期：2009-07-01 00:00:00

abstract：:Hypertriglyceridemia is a common complex metabolic trait that is associated with increased atherosclerosis risk, presence of the metabolic syndrome and, with extreme elevation, increased risk of pancreatitis. Hierarchical cluster analysis using clinical and biochemical features of the Frederickson hyperlipoproteinemia...

journal_title：Molecular and cellular biochemistry

authors： Hegele RA,Pollex RL

更新日期：2009-06-01 00:00:00

abstract：:The molecular mechanism of fatty acid uptake and utilization is of high medical relevance for the treatment of obesity, diabetes, and cardiovascular disease. Neuronal processes, hormones, and transcription factors are master regulators of these essential processes while their fine-tuning is achieved by modulating the ...

journal_title：Molecular and cellular biochemistry

authors： Digel M,Ehehalt R,Stremmel W,Füllekrug J

更新日期：2009-06-01 00:00:00

abstract：:The fatty acid binding proteins (FAPBs) function as intracellular carriers of fatty acid (FA) and related compounds. During the digestion of lipids, the local concentration of FA exceeds their critical micellar concentration; the excess ratio of FA/FABP can be as high as approximately 1,000/1, consequently building mi...

journal_title：Molecular and cellular biochemistry

authors： Levin LB,Nachliel E,Gutman M,Tsfadia Y

更新日期：2009-06-01 00:00:00

abstract：:Cervical cancer is the most common cancer in Indian females and is associated with infection with high risk Human papillomaviruses (HPVs). Curcumin (Diferuloyl methane), a chemopreventive agent, is a natural compound extracted from Curcuma longa that allows suppression of carcinogenesis. The objective of this study wa...

journal_title：Molecular and cellular biochemistry

authors： Singh M,Singh N

更新日期：2009-05-01 00:00:00

abstract：:Although studies performed in vitro and with transfected cells in culture suggest a role for liver fatty acid binding protein (L-FABP) in regulating fatty acid oxidation and fat deposition, the physiological significance of this possibility is not completely clear. To begin to address this question, the effect of L-FA...

journal_title：Molecular and cellular biochemistry

authors： Martin GG,Atshaves BP,McIntosh AL,Payne HR,Mackie JT,Kier AB,Schroeder F

更新日期：2009-04-01 00:00:00

abstract：:Ghrelin and obestatin are two peptide hormones with opposing roles in the control of appetite: orexigenic and anorexigenic, respectively. Loss of appetite is a common, serious complication of many forms of malignancy. The goals of this study were to investigate: (i) whether there are differences in ghrelin and obestat...

journal_title：Molecular and cellular biochemistry

authors： Karaoglu A,Aydin S,Dagli AF,Cummings DE,Ozercan IH,Canatan H,Ozkan Y

更新日期：2009-03-01 00:00:00

abstract：:The effect of increased serum levels of thyroid hormone (triiodothyronine, T3) on young rat testis spermatogenesis was studied by analysing molecular and morphological parameters. Hyperthyroidism was induced by either T3-treatment or 2- and 10-day cold exposure. The poly(ADP-ribosyl)ation of proteins catalysed by poly...

journal_title：Molecular and cellular biochemistry

authors： Faraone-Mennella MR,Ferone A,Marino L,Cardone A,Comitato R,Venditti P,Di Meo S,Farina B

更新日期：2009-03-01 00:00:00

abstract：:Migration and proliferation of smooth muscle cells (SMC) are important events during arteriogenesis, but the underlying mechanism is still only partially understood. The present study investigates the expression of integrins alpha 5 beta 1 and v beta 3 as well as focal adhesion kinase (FAK) and phosphorylated FAK (pY3...

journal_title：Molecular and cellular biochemistry

authors： Cai WJ,Li MB,Wu X,Wu S,Zhu W,Chen D,Luo M,Eitenmüller I,Kampmann A,Schaper J,Schaper W

更新日期：2009-02-01 00:00:00

abstract：:We assessed whether aging augments left ventricular (LV) damage, remodeling, and dysfunction and alters expression of healing-specific-matricellular proteins (HSMPs), matrix metalloproteinases (MMPs) and other pertinent proteins after acute reperfused-ST-segment-elevation myocardial infarction (RSTEMI) in the dog mode...

journal_title：Molecular and cellular biochemistry

authors： Jugdutt BI,Palaniyappan A,Uwiera RR,Idikio H

更新日期：2009-02-01 00:00:00

abstract：:Liver-specific ZP domain-containing protein (LZP) was recently identified as a secreted protein that is specifically expressed in liver. However, the physiological effects of LZP are largely unknown. In this study, we found that LZP was detectable in mouse kidneys, testes, ovaries and heart, in addition to liver. LZP ...

journal_title：Molecular and cellular biochemistry

authors： Shen HL,Xu ZG,Huang LY,Liu D,Lin DH,Cao JB,Zhang X,Wang ZQ,Wang WH,Yang PY,Han ZG

更新日期：2009-01-01 00:00:00

abstract：:The aim of our work was to study (1) the antioxidant properties of lipoic acid (LA) and its reduced metabolite dihydrolipoic acid (DHLA) formed by reduction of LA and (2) the effects of treatment with LA and DHLA on (a) K(+) efflux from human red blood cells and (b) post-ischemic recovery and oxidative stress in isola...

journal_title：Molecular and cellular biochemistry

authors： Ghibu S,Lauzier B,Delemasure S,Amoureux S,Sicard P,Vergely C,Muresan A,Mogosan C,Rochette L

更新日期：2009-01-01 00:00:00

abstract：:The roles of TGF-beta and the interaction between TGF-beta and EGFR signaling are critical in Sertoli cell, though the knowledge about them is limited. RT-PCR was used to characterize the status of TGF-beta signaling in clinical testicular specimens with complete Sertoli cell-only syndrome (SCOS). The mouse Sertoli ce...

journal_title：Molecular and cellular biochemistry

authors： Sun T,Xin Z,Jin Z,Wu Y,Gong Y

更新日期：2008-12-01 00:00:00